Article
Overt and covert genetic causes of pediatric acute lymphoblastic leukemia.
Leukemia - 1 May 2025
Stoltze Ulrik, Junk Stefanie V, Byrjalsen Anna, Cavé Hélène, Cazzaniga Giovanni, Elitzur Sarah, Fronkova Eva, Hjalgrim Lisa Lyngsie, Kuiper Roland P, Lundgren Louise, Mescher Melina, Mikkelsen Theis, Pastorczak Agata, Strullu Marion, Trka Jan, Wadt Karin, Izraeli Shai, Borkhardt Arndt, Schmiegelow Kjeld
Abstract excerpt
Pediatric acute lymphoblastic leukemia (pALL) is the most common childhood malignancy, yet its etiology remains incompletely understood. However, over the course of three waves of germline genetic research, several non-environmental causes have been identified. Beginning with trisomy 21, seven overt cancer predisposition syndromes (CPSs)-characterized by broad clinical phenotypes that include an elevated risk of...
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