Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers.

doi:10.1038/s41467-024-48363-5

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Article

Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers.

Nature communications - 16 May 2024

Deyell Rebecca J, Shen Yaoqing, Titmuss Emma, Dixon Katherine, Williamson Laura M, Pleasance Erin, Nelson Jessica M T, Abbasi Sanna, Krzywinski Martin, Armstrong Linlea, Bonakdar Melika, Ch'ng Carolyn, Chuah Eric, Dunham Chris, Fok Alexandra, Jones Martin, Lee Anna F, Ma Yussanne, Moore Richard A, Mungall Andrew J, Mungall Karen L, Rogers Paul C, Schrader Kasmintan A, Virani Alice, Wee Kathleen, Young Sean S, Zhao Yongjun, Jones Steven J M, Laskin Janessa, Marra Marco A, Rassekh Shahrad R

Abstract excerpt

The role for routine whole genome and transcriptome analysis (WGTA) for poor prognosis pediatric cancers remains undetermined. Here, we characterize somatic mutations, structural rearrangements, copy number variants, gene expression, immuno-profiles and germline cancer predisposition variants in children and adolescents with relapsed, refractory or poor prognosis malignancies who underwent somatic WGTA and...

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Identifiers

PMID: 38755180
DOI: 10.1038/s41467-024-48363-5
PMCID: PMC11099106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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