Article
A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.
Blood - 22 Jan 2015
Perez-Andreu Virginia, Roberts Kathryn G, Xu Heng, Smith Colton, Zhang Hui, Yang Wenjian, Harvey Richard C, Payne-Turner Debbie, Devidas Meenakshi, Cheng I-Ming, Carroll William L, Heerema Nyla A, Carroll Andrew J, Raetz Elizabeth A, Gastier-Foster Julie M, Marcucci Guido, Bloomfield Clara D, Mrózek Krzysztof, Kohlschmidt Jessica, Stock Wendy, Kornblau Steven M, Konopleva Marina, Paietta Elisabeth, Rowe Jacob M, Luger Selina M, Tallman Martin S, Dean Michael, Burchard Esteban G, Torgerson Dara G, Yue Feng, Wang Yanli, Pui Ching-Hon, Jeha Sima, Relling Mary V, Evans William E, Gerhard Daniela S, Loh Mignon L, Willman Cheryl L, Hunger Stephen P, Mullighan Charles G, Yang Jun J
Abstract excerpt
Acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA) is characterized by distinct presenting features and inferior prognosis compared with pediatric ALL. We performed a genome-wide association study (GWAS) to comprehensively identify inherited genetic variants associated with susceptibility to AYA ALL. In the discovery GWAS, we compared genotype frequency at 635 297 single nucleotide...
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