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Article

Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries.

Nature communications - 5 May 2026

Haydarlou Poeya, Kramarenko Daria R, Enzan Nobuyuki, Klevjer Marie, Vad Oliver B, Corver Marre E, Zimmerman Dominic S, Matsuda Koichi, Diederichsen Søren Z, Bye Anja, Svendsen Jesper H, Ito Kaoru, Ellinor Patrick T, Bezzina Connie R, Jurgens Sean J

Abstract excerpt

Polygenic scores can improve atrial fibrillation risk prediction. However, limited accuracy and cross-ancestry transferability hinder clinical translation. Here, we explore several ensemble approaches to generate ancestry-optimized polygenic scores, with development in diverse participants from the All of Us Research Program, BioBank Japan, and three additional cohorts. Our ancestry-specific multi-trait approach...

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PMID: 42086565
DOI: 10.1038/s41467-026-72708-x
PMCID: PMC13350093

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