Article

Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk

2021-09-12

Abstract excerpt

To understand the genetic underpinnings of atrial fibrillation (AF) in the Japanese population, we performed a large-scale genome-wide association study comprising 9,826 cases of AF among 150,272 individuals and identified five new susceptibility loci, including East Asian-specific rare variants. A trans-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 novel loci. Leveraging...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 207bbd12-141b-5773-9d02-3ccfb0f68fa8
DOI: 10.1101/2021.09.06.21263189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic riskDOI 10.1101/2021.09.06.21263189Read

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.Semantic proximity Read

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.Semantic proximity Read

Genetics of atrial fibrillation-an update of recent findings.Semantic proximity Read

Genomics of Atrial Fibrillation.Semantic proximity Read

Genetics of Atrial Fibrillation in 2020: GWAS, Genome Sequencing, Polygenic Risk, and Beyond.Semantic proximity Read

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.Semantic proximity Read

Heritability of Atrial Fibrillation.Semantic proximity Read

Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries.Semantic proximity Read

Genetic Risk Prediction of Atrial FibrillationSemantic proximity Read

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke SubtypesSemantic proximity Read

Deciphering the genetic architecture of atrial fibrillation offers insights into disease prediction, pathophysiology and downstream sequelaeSemantic proximity Read