Article

Combining clinical and polygenic risk improves stroke prediction among individuals with atrial fibrillation

2020-06-20

Abstract excerpt

<h4>Background</h4> Atrial fibrillation (AF) is associated with a five-fold increased risk of ischemic stroke. A portion of this risk is heritable, however current risk stratification tools (CHA2DS2-VASc) don’t include family history or genetic risk. We hypothesized that we could improve ischemic stroke prediction in patients with AF by incorporating polygenic risk scores (PRS). <h4>Objectives</h4> To construct an...

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Literature Corpus work: 662c3aef-566f-5854-8350-6ec2b356cfd6
DOI: 10.1101/2020.06.17.20134163

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