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Combining polygenic and clinical risk scores in atrial fibrillation risk prediction: Implications for population screening.

Heart rhythm - 1 Aug 2025

Segan Louise, Ho Ho William Wing, Crowley Rose, William Jeremy, Cho Kenneth, Prabh Sandeep, Chieng David, Sugumar Hariharan, Voskoboinik Aleksandr, Ling Liang-Han, Kalman Jonathan M, Abrams Dominic, Fatkin Diane, Takeuchi Fumihiko, Kistler Peter M

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) development is determined by clinical risk factors and genetic predisposition. Few studies have explored whether incorporating polygenic risk scores (PRS) improves clinical-risk prediction beyond existing models. OBJECTIVES: We evaluated the interaction between AF-PRS and the hypertension, age, raised body mass index, male sex, sleep apnea, and smoking-AF (HARMS2-AF) and...

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PMID: 40288473
DOI: 10.1016/j.hrthm.2025.04.032

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