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Article

PRISM-xQTL: Pleiotropic Relationships Integrated with System-level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Enduru Nitesh, Zhao Zhongming

Abstract excerpt

INTRODUCTION: Most Alzheimer's disease (AD) risk variants identified by genome-wide association studies (GWAS) reside in noncoding regions, complicating causal interpretation. METHODS: We developed PRISM-xQTL (Pleiotropic Relationships Integrated with System-level Multiomic QTL), integrating pleiotropy, co-localization, Mendelian randomization, and mediation analyses across multiomic quantitative trait loci...

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Source

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Identifiers

PMID: 41611629
DOI: 10.1002/alz.71073
PMCID: PMC12854938

Genes

FCER1G
ELL
ISYNA1
TSPAN14

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