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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies<i>LRRC4C, LHX5-AS1</i>and nominates ancestry-specific loci<i>PTPRK</i>,<i>GRB14</i>, and<i>KIAA0825</i>as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium

2023-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer’s Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture...

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Literature Corpus work
9bd0ad55-8bfe-55ea-81ea-61520b9b6dc5
DOI
10.1101/2023.07.06.23292311
Open publication

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies<i>LRRC4C, LHX5-AS1</i>and nominates ancestry-specific loci<i>PTPRK</i>,<i>GRB14</i>, and<i>KIAA0825</i>as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics ConsortiumDOI 10.1101/2023.07.06.23292311
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