Article
Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2024
Lee Wan-Ping, Choi Seung Hoan, Shea Margaret G, Cheng Po-Liang, Dombroski Beth A, Pitsillides Achilleas N, Heard-Costa Nancy L, Wang Hui, Bulekova Katia, Kuzma Amanda B, Leung Yuk Yee, Farrell John J, Lin Honghuang, Kunkle Brian W, Naj Adam, Blue Elizabeth E, Nusetor Frederick, Wang Dongyu, Boerwinkle Eric, Bush William S, Zhang Xiaoling, De Jager Philip L, Dupuis Josée, Farrer Lindsay A, Fornage Myriam, Martin Eden, Pericak-Vance Margaret, Seshadri Sudha, Wijsman Ellen M, Wang Li-San, Schellenberg Gerard D, Destefano Anita L, Haines Jonathan L, Peloso Gina M
Abstract excerpt
INTRODUCTION: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. METHODS: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data. RESULTS: Pooled-population analyses of all individuals identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.