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Article

Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of Alzheimer's Disease.

ACS chemical neuroscience - 21 Jan 2026

Mishra Ashwini Kumar, Jain Smita

Abstract excerpt

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by complex genetic and molecular interactions. Despite major advances in genomics, current discoveries explain less than 40% of AD heritability, underscoring the need for integrative approaches that capture cross-omic regulation. Here, we propose a multiomics integration framework combining genomic, epigenomic, and transcriptomic data...

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Identifiers

PMID: 41422555
DOI: 10.1021/acschemneuro.5c00750

Genes

AKT1
APOE
BIN1
CLU
DOT1L
PICALM
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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