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Article

Insights into the Cross-Population Transferability of Polygenic Scores for Substance Use.

Behavior genetics - 1 May 2026

Saunders Gretchen R B, Vrieze Scott, Liu Dajiang J

Abstract excerpt

Polygenic scores have potential for predicting health outcomes based on genomic data. However, their portability across diverse populations is hindered by the overrepresentation of European ancestries in discovery genome-wide association (GWAS) studies. The current study evaluated the transferability of substance use polygenic scores across European, African, American, and East Asian populations. European-based...

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Identifiers

PMID: 42050232
DOI: 10.1007/s10519-026-10265-1
PMCID: PMC13201358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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