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Article

Three open questions in polygenic score portability.

Nature communications - 26 Jan 2026

Wang Joyce Y, Lin Neeka, Zietz Michael, Mares Jason, Smith Olivia S, Rathouz Paul J, Harpak Arbel

Abstract excerpt

The broad adoption of polygenic scores (PGS) is hindered by their limited portability to people that differ-in genetic ancestry or other characteristics-from the GWAS samples used to construct them. Here, we measure PGS prediction accuracy as a continuous function of individuals' genome-wide genetic dissimilarity to the GWAS sample (genetic distance). Our results highlight three gaps in our understanding of PGS...

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Share to Models, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41587969
DOI: 10.1038/s41467-026-68565-3
PMCID: PMC12835231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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