Article
The impact of diverse ancestry on polygenic risk score-based prediction models for psychiatric and neurodevelopmental disorders.
Psychiatry research - 1 Oct 2026
Nudel Ron, Appadurai Vivek, Thompson Wesley K, Børglum Anders D, Werge Thomas, Benros Michael E
Abstract excerpt
Precision psychiatry aims to include genetic risk assessed via polygenic risk scores (PRSs) in risk prediction models. A major challenge to health equality is that the predictive accuracy of PRSs decreases when the training and target populations are of different ancestries. However, no prior study has systematically investigated the degree of reduction or loss of specificity for multiple psychiatric disorders....
Topics
Join the communities discussing this publication.