Article

Toward Clinical Implementation of Polygenic Scores for Substance Use Disorders: A Multi-Ancestry Study

2026-07-06

Abstract excerpt

<h4>Objective</h4> To develop and validate clinically relevant polygenic scores (PGS) for alcohol (AUD), cannabis (CanUD), opioid (OUD), tobacco (TUD), and polysubstance use disorders (polySUD) across African (AA), European (EA), and Latinx (LA) ancestry populations. <h4>Methods</h4> Using multiple genome-wide association study summary statistics and PGS methods, substance use disorder PGS were developed and eva...

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Literature Corpus work: e30daae9-9838-5585-ae51-f052399dd39d
DOI: 10.64898/2026.07.03.26357210

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