Article

Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index

2022-05-28

Abstract excerpt

Polygenic risk scores (PRS) have led to enthusiasm for precision medicine. However, it is well documented that PRS do not generalize across groups differing in ancestry or sample characteristics e.g., age. Quantifying performance of PRS across different groups of study participants, using genome-wide association study (GWAS) summary statistics from multiple ancestry groups and sample sizes, and using different lin...

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Literature Corpus work: 2e745365-819d-5dbd-8565-fa5993521be3
DOI: 10.1101/2022.05.27.22275647

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