Article

Polygenic transcriptome risk scores improve portability of polygenic risk scores across ancestries

2020-11-13

Abstract excerpt

Polygenic risk scores (PRS) are on course to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry, meaning that the utility of PRS for non-European populations is limited because SNP effects and LD patterns may not be conserved across populations. We hypothesized that cross population prediction at the level o...

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Literature Corpus work: 3efccee4-618d-5e74-9914-78f090d6feea
DOI: 10.1101/2020.11.12.373647

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