Article

Current clinical use of polygenic scores will risk exacerbating health disparities

2018-10-11

Abstract excerpt

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation is that they are many-fold more accurate in European ancestry individuals than others. This disparity is an inescapable consequence of Eurocentric genome-wide association study biases. This highlights that—unlike clinical biomarkers...

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Literature Corpus work: 712f5970-c817-51da-8751-f173f25e6b47
DOI: 10.1101/441261

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