Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort.

Abstract excerpt

The low portability of polygenic scores (PGSs) across global populations is a major concern that must be addressed before PGSs can be used for everyone in the clinic. Indeed, prediction accuracy has been shown to decay as a function of the genetic distance between the training and test cohorts. However, such cohorts differ not only in their genetic distance but also in their geographical distance and their data...

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• Algorithms
• Biological Specimen Banks
• Genetic Association Studies
• Genetics, Population
• Models, Genetic