Article

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysis

2025-06-06

Abstract excerpt

Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by complex, cell-type-specific molecular alterations. This study integrates single-cell RNA sequencing (scRNA-seq) with network-based methodologies to decode transcriptional changes across major brain cell types in AD. Using scRNA-seq data from 432,555 single cells, we constructed Protein-Protein Interaction (PPI) networks specific to each cell...

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Identifiers and source

Literature Corpus work: 589857ae-49ae-5afc-b05b-b6889e939660
DOI: 10.1101/2025.06.03.657612

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