Article

Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer’s Disease Dementia

2025-05-28

Abstract excerpt

Existing TWASs of AD dementia typically use a single statistical method to identify cell-type-specific risk genes. Here we sought to improve on existing approaches and utilized an omnibus xWAS pipeline to integrate snRNA-seq dataset (n=415) of dorsolateral prefrontal cortex (DLPFC) and the latest GWAS data of AD dementia to detect cell-type-specific risk genes. We identified 223 cell-type-specific TWAS risk genes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ddb58886-1b19-598e-bd98-5ce4e2161d41
DOI: 10.1101/2025.05.27.25328452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer’s Disease DementiaDOI 10.1101/2025.05.27.25328452Read

Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer's disease dementia.Semantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer’s DiseaseSemantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read

Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer’s disease dementiaSemantic proximity Read

Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson’s diseaseSemantic proximity Read

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer’s diseaseSemantic proximity Read

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Semantic proximity Read

Single-cell multiomics reveals disrupted glial gene regulatory programs in Alzheimer’s disease via interpretable machine learningSemantic proximity Read

The Alzheimer's Cell Atlas (TACA): A single‐cell molecular map for translational therapeutics accelerator in Alzheimer's diseaseSemantic proximity Read

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomicsSemantic proximity Read

The genetic architecture of dementia risk: how Alzheimer’s disease vulnerability converges on lipid metabolism and immune cell networksSemantic proximity Read