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Article

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.

Alzheimer's research & therapy - 18 Jun 2025

Hu Tingyang, Liu Qiang, Dai Qile, Buchman Aron S, Bennett David A, Tasaki Shinya, Wang Yanling, Seyfried Nicholas T, De Jager Philip L, Epstein Michael P, Yang Jingjing

Abstract excerpt

BACKGROUND: A proteome-wide association study (PWAS) that integrates proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer's disease (AD) dementia. Existing PWAS analyses of AD often rely on the availability of individual-level proteomic and genetic data of a reference panel. Leveraging summary protein quantitative trait loci (pQTL) reference data of...

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Identifiers

PMID: 40533815
DOI: 10.1186/s13195-025-01774-y
PMCID: PMC12175411

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APOE
MAPK3

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