Article

Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson’s disease

2026-05-25

Abstract excerpt

To better illustrate the genetic etiology of Parkinson’s disease (PD), we integrated xQTL weights derived from bulk RNA-seq (n=931), single-nucleus RNA-seq (n=415), and bulk proteomics (n=716) data of dorsolateral prefrontal cortex (DLPFC) with the largest available GWAS summary data of PD. Through integrative Omnibus TWAS and PWAS analyses, we detected risk genes whose genetic effects are mediated through bulk or...

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Literature Corpus work: c9c71573-55ad-5dea-8760-a969628b2f12
DOI: 10.64898/2026.05.23.26353951

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