Article

Omnibus proteome-wide association study (PWAS-O) identified 43 risk genes for Alzheimer’s disease dementia

2022-12-27

Abstract excerpt

Proteome-wide association study (PWAS) integrating proteomics data with GWAS data is a powerful tool to identify risk genes for complex diseases, which can inform disease mechanisms with genetic effects mediated through protein abundance. We propose a novel omnibus method to improve PWAS power by modeling unknown genetic architectures with multiple statistical models. We applied TIGAR, PrediXcan, and FUSION to tra...

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Literature Corpus work: 9ef0ac71-30e3-5d69-933b-fa6c61c524af
DOI: 10.1101/2022.12.25.22283936

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