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Article

Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes.

Journal of the American Heart Association - 5 May 2026

He Yijie, Zhang Tao, Zhu Ping, Gao Shan, Wu Shiyang, Liu Fengzhen, Chen Yan, Yao Yingshui, Liu Guiyou

Abstract excerpt

BACKGROUND: Previous studies have integrated genome-wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell-type specificity, and genetic variants may have distinct effects across stroke subtypes. METHODS: We applied the summary-data-based Mendelian randomization (MR) method to integrate eQTL data...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42003665
DOI: 10.1161/JAHA.125.046208
PMCID: PMC13279166

Genes

LIPA
CENPQ
AHI1
ELL
ICA1L
LYRM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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