Article

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease

2024-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified numerous genetic loci influencing human disease risk. However, linking these loci to causal genes remains challenging, limiting opportunities for drug target discovery. Transcriptome-wide association studies (TWAS) address this by linking variants to gene expression, but typically rely on bulk RNA sequencing, which lacks cell-specific resolut...

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Literature Corpus work: 8e30343a-dcaa-59de-8faa-f6c11963db62
DOI: 10.1101/2024.12.19.24319316

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