Article

Causal Genetic Mechanisms of Hyperhomocysteinemia in Ischemic Stroke: Integrating Mendelian Randomization, Single-Cell Transcriptomics, and Machine Learning

2026-09-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Hyperhomocysteinemia has been widely linked to the development of cerebrovascular diseases, yet the cell type-specific genetic mechanisms remain elusive. This study aimed to identify hyperhomocysteinemia-driven genes and their functional roles in specific cell populations underlying ischemic stroke (IS) pathogenesis. <bold>Methods:</bold> Data were obtained...

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Literature Corpus work: d97928c6-aa17-5149-9b10-ba66db9bec1b
DOI: 10.21203/rs.3.rs-10770596/v1

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