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Article

Integration of Mendelian randomisation and systems biology models to identify novel blood-based biomarkers for stroke.

Journal of biomedical informatics - 1 May 2023

Islam Tania, Rahman Md Rezanur, Khan Asaduzzaman, Moni Mohammad Ali

Abstract excerpt

Stroke is the second largest cause of mortality in the world. Genome-wide association studies (GWAS) have identified some genetic variants associated with stroke risk, but their putative functional causal genes are unknown. Hence, we aimed to identify putative functional causal gene biomarkers of stroke risk. We used a summary-based Mendelian randomisation (SMR) approach to identify the pleiotropic associations...

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PMID: 36958462
DOI: 10.1016/j.jbi.2023.104345

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