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Article

Identifying therapeutic target genes for stroke through systematic druggable Mendelian randomization analysis.

Medicine - 8 May 2026

Xia Jiangliu, Zheng Jia, Zou Shengmei, Zhao Hua, Liu Qiang, Zhang Ruoyu, Xu Lei

Abstract excerpt

Stroke remains a major cause of mortality and disability, highlighting the need for new therapeutic targets. This study aimed to systematically identify druggable genes causally associated with stroke risk using genetic and transcriptomic data. A total of 5883 druggable genes were compiled from the Drug-Gene Interaction Database and previous reviews. We integrated data from a large-scale stroke GWAS with blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42116389
DOI: 10.1097/MD.0000000000048634
PMCID: PMC13166711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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