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Article

Bayesian colocalization of GWAS and eQTL signals reveals cell type-specific genes and regulatory variants for susceptibility to subtypes of ischemic stroke.

Computational biology and chemistry - 1 Jun 2024

Seo Yunji, Bae Hojin, Lee Chaeyoung

Abstract excerpt

A colocalization analysis of genome-wide association study (GWAS) signals and expression quantitative trait loci (eQTL) was conducted to pinpoint target genes and their regulatory nucleotide variants for subtypes of ischemic stroke. We utilized GWAS data from prominent meta-analysis consortia (MEGASTROKE and GIGASTROKE) and single-cell eQTL data in brain and blood tissues to enhance accuracy and minimize noise...

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PMID: 38744227
DOI: 10.1016/j.compbiolchem.2024.108086

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