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Article

Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study.

Human molecular genetics - 7 Jan 2024

Jung Junghyun, Lu Zeyun, de Smith Adam, Mancuso Nicholas

Abstract excerpt

Stroke, characterized by sudden neurological deficits, is the second leading cause of death worldwide. Although genome-wide association studies (GWAS) have successfully identified many genomic regions associated with ischemic stroke (IS), the genes underlying risk and their regulatory mechanisms remain elusive. Here, we integrate a large-scale GWAS (N = 1 296 908) for IS together with molecular QTLs data,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37824084
DOI: 10.1093/hmg/ddad174
PMCID: PMC10772041

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