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Article

Yeast Phenomic Analysis Reveals DNA Repair, pH Homeostasis, and Ribosomal Biogenesis as Modulators of Anticancer Ruthenium Complex KP1019.

International journal of molecular sciences - 4 Apr 2026

Bible Amanda F, Blackman Jackson S, Rodgers John W, Gary Samuel R, Rainey Megan, Miller Mary E, Stepanov Alexander, Hartman John L, Stultz Laura K, Hanson Pamela K

Abstract excerpt

The anticancer ruthenium complex indazolium trans-[tetrachlorobis(1H-indazole) ruthenate (III)-also known as KP1019-inhibits cancer cell proliferation in vitro, causes tumor regression in animal models, and showed no dose-limiting toxicity in a phase I clinical trial. Previous studies found that KP1019 damages DNA in both cancer cells and the budding yeast Saccharomyces cerevisiae. To identify other potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41977453
DOI: 10.3390/ijms27073275
PMCID: PMC13073065

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