Article
Genome instability footprint under rapamycin and hydroxyurea treatments.
PLoS genetics - 1 Nov 2023
Li Jing, Stenberg Simon, Yue Jia-Xing, Mikhalev Ekaterina, Thompson Dawn, Warringer Jonas, Liti Gianni
Abstract excerpt
The mutational processes dictating the accumulation of mutations in genomes are shaped by genetic background, environment and their interactions. Accurate quantification of mutation rates and spectra under drugs has important implications in disease treatment. Here, we used whole-genome sequencing and time-resolved growth phenotyping of yeast mutation accumulation lines to give a detailed view of the mutagenic...
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