Article

PI3K/mTOR activity sensitizes cancer cells to nucleolar stress

2025-11-13

Abstract excerpt

<h4>SUMMARY</h4> Drugs targeting nucleoli and generating nucleolar stress (NS) such as RNA Polymerase I inhibitors have shown anticancer properties with some progressing to clinical trials. However, the mechanisms that modulate the sensitivity to NS remain poorly understood, which has limited the design of clinical trials on patients most likely responding to these therapies. To get a panoramic view of the geneti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 766886bf-641a-5603-8b8e-91669cea7225
DOI: 10.1101/2025.11.12.688066

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PI3K/mTOR activity sensitizes cancer cells to nucleolar stressDOI 10.1101/2025.11.12.688066Read

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicitySemantic proximity Read

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathwaySemantic proximity Read

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11Semantic proximity Read

Targeting RNA polymerase I transcription and the nucleolus for cancer therapySemantic proximity Read

A consensus set of genetic vulnerabilities to ATR inhibitionSemantic proximity Read

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stressSemantic proximity Read

Genome instability footprint under rapamycin and hydroxyurea treatmentsSemantic proximity Read

A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseSemantic proximity Read

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read

Small-molecule drug repurposing to target DNA damage repair and response pathwaysSemantic proximity Read

The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high <i>MYC</i> malignanciesSemantic proximity Read