Article
A humanized yeast phenomic model of deoxycytidine kinase to predict genetic buffering of nucleoside analog cytotoxicity
2019-07-22
Abstract excerpt
Knowledge about synthetic lethality can be applied to enhance the efficacy of anti-cancer therapies in individual patients harboring genetic alterations in their cancer that specifically render it vulnerable. We investigated the potential for high-resolution phenomic analysis in yeast to predict such genetic vulnerabilities by systematic, comprehensive, and quantitative assessment of drug-gene interaction for gemc...
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Identifiers and source
- Literature Corpus work
- 08b4ae0c-3c7d-57d0-8d60-e4268dee863f
- DOI
- 10.1101/700153