Article

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines

2026-04-28

Abstract excerpt

Aneuploidy is a hallmark of cancer and imposes widespread cellular stress, including proteotoxicity, transcriptional dysregulation, and increased metabolic demand. Although these stresses are predicted to create therapeutic vulnerabilities, the genetic dependencies of aneuploid cells remain incompletely characterized. Here, we performed paired CRISPR loss-of-function screens in isogenic aneuploid and near-euploid...

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Literature Corpus work: 1550e0dd-09e2-5cf0-84cd-ed28dcbb72f8
DOI: 10.64898/2026.04.26.720636

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Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell linesDOI 10.64898/2026.04.26.720636Read

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