Article

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer.

2026-08-26

Abstract excerpt

We previously reported that the phosphate exporter XPR1 is required to prevent toxic phosphate accumulation in ovarian cancer cells. To guide therapeutic development, we sought to systematically compare potential strategies to inhibit XPR1: directly targeting the phosphate efflux channel, targeting its partner protein KIDINS220, or inhibiting the synthesis of inositol pyrophosphates (PP-InsPs), metabolites which a...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 6a6530b8-9aa4-5890-8fac-b4a950bda5bc
DOI: 10.64898/2026.08.25.747159

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer.DOI 10.64898/2026.08.25.747159Read

Epidrug Screening Identifies Type I PRMT Inhibitors as Modulators of Lysosomal Exocytosis and Drug Sensitivity in CancersSemantic proximity Read

Yeast Phenomic Analysis Reveals DNA Repair, pH Homeostasis, and Ribosomal Biogenesis as Modulators of Anticancer Ruthenium Complex KP1019.Semantic proximity Read

Transport and InsP8 activation mechanisms of the human inorganic phosphate exporter XPR1Semantic proximity Read

INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.Semantic proximity Read

Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.Semantic proximity Read

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethalitySemantic proximity Read

NPEPPS is a novel and druggable driver of platinum resistanceSemantic proximity Read

DCTPP1: A promising target in cancer therapy and prognosis through nucleotide metabolismSemantic proximity Read

In silico engineered multitarget-directed ligands for the polypharmaceutical treatment of PTEN loss of function endometrial adenocarcinomaSemantic proximity Read

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growthSemantic proximity Read

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer modelsSemantic proximity Read

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replicationSemantic proximity Read