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Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping.

Molecular cancer research : MCR - 1 Dec 2002

Begley Thomas J, Rosenbach Ari S, Ideker Trey, Samson Leona D

Abstract excerpt

We have generated a genomic phenotyping database identifying hundreds of Saccharomyces cerevisiae genes important for viable cellular recovery after mutagen exposure. Systematic phenotyping of 1,615 gene deletion strains produced distinctive signatures for each of four mutagens. Integration of the phenotyping database with mutagen-induced transcriptional profiling data demonstrated that being transcriptionally...

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PMID: 12496357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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