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Article

Overexpression of genes involved in vesicular trafficking to the vacuole defends against lethal effects of oxidative damage.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 2003

Martinez M, Pramanik A, Moto-Ndje S, Moore C W

Abstract excerpt

Anticancer bleomycins and structurally-related analogs are oxidative agents that mimic ionizing radiation in many of their cellular effects. The current study was designed to better understand this class of radiomimetic and oxidative drugs, and how cells defend against them to become resistant. Based on some of the properties conferred by the blm5-1 mutation of Saccharomyces cerevisiae, a multi-step cloning...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14682384

Genes

VPS8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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