Article
Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 30 Mar 2026
Huang Pang-Shuo, Li Guan-Wei, Cheng Jen-Fang, Chen Jien-Jiun, Ho Li-Ting, Lin Ting-Tse, Chiu Fu-Chun, Wu Cho-Kai, Chang Sheng-Nan, Chuang Eric Y, Wang Yi-Chih, Tsai Chia-Ti
Abstract excerpt
AIMS: Prolonged QT interval is a well-established marker for malignant ventricular arrhythmias and sudden cardiac death (SCD). Although previous genome-wide association studies (GWASs) have identified multiple QT-associated loci, most were conducted in European cohorts, limiting generalizability to East Asian populations. This study aimed to identify genetic determinants of QTc interval in a Taiwanese population....
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