Article
Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.
Circulation. Cardiovascular genetics - 1 Jun 2011
Noseworthy Peter A, Havulinna Aki S, Porthan Kimmo, Lahtinen Annukka M, Jula Antti, Karhunen Pekka J, Perola Markus, Oikarinen Lasse, Kontula Kimmo K, Salomaa Veikko, Newton-Cheh Christopher
Abstract excerpt
BACKGROUND: Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD. METHODS AND RESULTS: We genotyped 15 common (minor allele frequency >1%) candidate single...
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