Article
GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.
Scientific reports - 6 Dec 2017
Méndez-Giráldez Raúl, Gogarten Stephanie M, Below Jennifer E, Yao Jie, Seyerle Amanda A, Highland Heather M, Kooperberg Charles, Soliman Elsayed Z, Rotter Jerome I, Kerr Kathleen F, Ryckman Kelli K, Taylor Kent D, Petty Lauren E, Shah Sanjiv J, Conomos Matthew P, Sotoodehnia Nona, Cheng Susan, Heckbert Susan R, Sofer Tamar, Guo Xiuqing, Whitsel Eric A, Lin Henry J, Hanis Craig L, Laurie Cathy C, Avery Christy L
Abstract excerpt
QT interval prolongation is a heritable risk factor for ventricular arrhythmias and can predispose to sudden death. Most genome-wide association studies (GWAS) of QT were performed in European ancestral populations, leaving other groups uncharacterized. Herein we present the first QT GWAS of Hispanic/Latinos using data on 15,997 participants from four studies. Study-specific summary results of the association...
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