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Article

A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.

American journal of human genetics - 13 Jul 2012

Kim Jong Wook, Hong Kyung-Won, Go Min Jin, Kim Sung Soo, Tabara Yasuharu, Kita Yoshikuni, Tanigawa Takeshi, Cho Yoon Shin, Han Bok-Ghee, Oh Bermseok

Abstract excerpt

Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, predisposes one to ventricular arrhythmias and sudden cardiac death. Since NOS1AP, a regulator of neuronal nitric oxide synthase, was discovered in a genome-wide association study (GWAS) as a novel target that modulates cardiac repolarization, several loci have been linked to the QT interval in studies (QTGEN and QTSCD) of...

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Identifiers

PMID: 22726844
DOI: 10.1016/j.ajhg.2012.05.019
PMCID: PMC3397256

Genes

MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.PMID 22726844Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Common candidate gene variants are associated with QT interval duration in the general population.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.Semantic proximity Read ↗

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.Semantic proximity Read ↗

Common variants at ten loci influence QT interval duration in the QTGEN Study.Semantic proximity Read ↗

NOS1AP Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

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