Article
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
PloS one - 9 Jul 2009
Nolte Ilja M, Wallace Chris, Newhouse Stephen J, Waggott Daryl, Fu Jingyuan, Soranzo Nicole, Gwilliam Rhian, Deloukas Panos, Savelieva Irina, Zheng Dongling, Dalageorgou Chrysoula, Farrall Martin, Samani Nilesh J, Connell John, Brown Morris, Dominiczak Anna, Lathrop Mark, Zeggini Eleftheria, Wain Louise V, Newton-Cheh Christopher, Eijgelsheim Mark, Rice Kenneth, de Bakker Paul I W, Pfeufer Arne, Sanna Serena, Arking Dan E, Asselbergs Folkert W, Spector Tim D, Carter Nicholas D, Jeffery Steve, Tobin Martin, Caulfield Mark, Snieder Harold, Paterson Andrew D, Munroe Patricia B, Jamshidi Yalda
Abstract excerpt
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT...
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