Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.

doi:10.1016/j.hrthm.2016.12.021

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Article

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.

Heart rhythm - 1 Apr 2017

Avery Christy L, Wassel Christina L, Richard Melissa A, Highland Heather M, Bien Stephanie, Zubair Niha, Soliman Elsayed Z, Fornage Myriam, Bielinski Suzette J, Tao Ran, Seyerle Amanda A, Shah Sanjiv J, Lloyd-Jones Donald M, Buyske Steven, Rotter Jerome I, Post Wendy S, Rich Stephen S, Hindorff Lucia A, Jeff Janina M, Shohet Ralph V, Sotoodehnia Nona, Lin Dan Yu, Whitsel Eric A, Peters Ulrike, Haiman Christopher A, Crawford Dana C, Kooperberg Charles, North Kari E

Abstract excerpt

BACKGROUND: The electrocardiographically measured QT interval (QT) is heritable and its prolongation is an established risk factor for several cardiovascular diseases. Yet, most QT genetic studies have been performed in European ancestral populations, possibly reducing their global relevance. OBJECTIVE: To leverage diversity and improve biological insight, we fine mapped 16 of the 35 previously identified QT loci...

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Identifiers

PMID: 27988371
DOI: 10.1016/j.hrthm.2016.12.021
PMCID: PMC5448160

Genes

NOS1AP
SCN10A
SCN5A
ATP1B1
CNOT1
KCNQ1
PLN
PRKCA
SLC35F1
TRPM7
USP50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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