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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

1 Sept 2022

Abstract excerpt

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively,...

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PMID: 36050321
DOI: 10.1038/s41467-022-32821-z

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