Article
Fine-mapping and initial characterization of QT interval loci in African Americans.
PLoS genetics - 1 Jan 2012
Avery Christy L, Sethupathy Praveen, Buyske Steven, He Qianchuan, Lin Dan-Yu, Arking Dan E, Carty Cara L, Duggan David, Fesinmeyer Megan D, Hindorff Lucia A, Jeff Janina M, Klein Liviu, Patton Kristen K, Peters Ulrike, Shohet Ralph V, Sotoodehnia Nona, Young Alicia M, Kooperberg Charles, Haiman Christopher A, Mohlke Karen L, Whitsel Eric A, North Kari E
Abstract excerpt
The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opportunities to narrow association signals and identify population-specific variants. We therefore evaluated 6,670 SNPs spanning eleven previously...
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