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Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

2021-11-04

Abstract excerpt

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a mal...

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Literature Corpus work
849c9937-42f0-5d1f-94b9-82d2c6b1367d
DOI
10.1101/2021.11.04.21265866
Open publication

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Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarizationDOI 10.1101/2021.11.04.21265866
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