Article
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nature genetics - 1 Apr 2009
Pfeufer Arne, Sanna Serena, Arking Dan E, Müller Martina, Gateva Vesela, Fuchsberger Christian, Ehret Georg B, Orrú Marco, Pattaro Cristian, Köttgen Anna, Perz Siegfried, Usala Gianluca, Barbalic Maja, Li Man, Pütz Benno, Scuteri Angelo, Prineas Ronald J, Sinner Moritz F, Gieger Christian, Najjar Samer S, Kao W H Linda, Mühleisen Thomas W, Dei Mariano, Happle Christine, Möhlenkamp Stefan, Crisponi Laura, Erbel Raimund, Jöckel Karl-Heinz, Naitza Silvia, Steinbeck Gerhard, Marroni Fabio, Hicks Andrew A, Lakatta Edward, Müller-Myhsok Bertram, Pramstaller Peter P, Wichmann H-Erich, Schlessinger David, Boerwinkle Eric, Meitinger Thomas, Uda Manuela, Coresh Josef, Kääb Stefan, Abecasis Gonçalo R, Chakravarti Aravinda
Abstract excerpt
The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and...
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