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Article

Opposing patterns of blood-brain barrier permeability and Alzheimer's disease biomarkers across APOE genotype.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 7 Apr 2026

Bernocchi Francesca, Bonomi Chiara Giuseppina, Poli Martina, Di Donna Martina Gaia, Terrinoni Alessandro, Motta Caterina, Martorana Alessandro

Abstract excerpt

BACKGROUND: APOE is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD), influencing both proteinopathies and cerebrovascular integrity. While the ε4 allele is well studied, the role of ε2—particularly in relation to blood-brain barrier (BBB) permeability—remains underexplored. OBJECTIVE: To investigate the association between APOE genotype, BBB permeability, and AD pathology in a large cohort...

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Identifiers

PMID: 41942760
DOI: 10.1007/s10072-026-08973-x

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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